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Proteome analysis of aged mouse oocytes

ABSTRACT: The proteome changes were quantified in aged mouse oocytes using TMT 6-plex by LC-MS/MS.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Oocyte

SUBMITTER: yao ping

LAB HEAD: Xuejiang Guo

PROVIDER: PXD023603 | Pride | 2022-02-16

REPOSITORIES: Pride

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			Action	DRS
	Mouse-AgingOocyte-TMT6.rar	Other
	Mouse-AgingOocyte-group1-TMT6-HPRP-1-20171116.raw	Raw
	Mouse-AgingOocyte-group1-TMT6-HPRP-10-20171118.raw	Raw
	Mouse-AgingOocyte-group1-TMT6-HPRP-11-20171119.raw	Raw
	Mouse-AgingOocyte-group1-TMT6-HPRP-12-20171119.raw	Raw

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Publications

Integrative proteome analysis implicates aberrant RNA splicing in impaired developmental potential of aged mouse oocytes.

Li Mingrui M Ren Chao C Zhou Shuai S He Yuanlin Y Guo Yueshuai Y Zhang Hao H Liu Lu L Cao Qiqi Q Wang Congjing C Huang Jie J Hu Yue Y Bai Xue X Guo Xuejiang X Shu Wenjie W Huo Ran R

Aging cell 20210928 10

Aging has many effects on the female reproductive system, among which decreased oocyte quality and impaired embryo developmental potential are the most important factors affecting female fertility. However, the mechanisms underlying oocyte aging are not yet fully understood. Here, we selected normal reproductively aging female mice and constructed a protein expression profile of metaphase II (MII) oocytes from three age groups. A total of 187 differentially expressed (DE) proteins were identifie ...[more]

PMID: 34582091

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