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Pathological Features of Enterovirus 71-associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analyses

ABSTRACT: Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, was first recognized as a dermotrophic virus that usually cause mild, self-limiting hand-foot-and-mouth disease (HFMD). However, EV71 infection can sometimes induce a variety of severe neurological complications, pulmonary edema and even death. Here, we aimed to provide an overview of proteomics characterization of EV71-infected brain and lung tissues.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Lung

SUBMITTER: Yuefei Jin

LAB HEAD: Yuefei Jin

PROVIDER: PXD023819 | Pride | 2021-09-10

REPOSITORIES: Pride

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Pathological Features of Enterovirus 71-Associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analysis.

Jin Yuefei Y Li Dong D Sun Tiantian T Du Yue Y Gao Yanlei Y Ding Ronghua R Ji Wangquan W Zhang Weiguo W Yang Haiyan H Chen Shuaiyin S Duan Guangcai G

Frontiers in microbiology 20210618

The outbreaks of enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD) have emerged as an emergency of global health due to its association with fatal encephalitis and subsequent neurogenic pulmonary edema; however, the molecular characteristics and pathological features underlying EV71-associated encephalitis and pulmonary edema remain largely unknown. In this study, we performed a proteomic analysis of fresh brain and lung tissues from EV71-infected mice at 7 days post infectio ...[more]

PMID: 34220748

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