Dataset Information

Systemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients with different forms of HFpEF to identify unique molecular mechanisms and pathways. We performed unbiased, comprehensive proteomic analyses of 31 gender- and BMI-matched plasma samples from patients with acute HFpEF (n=8), chronic HFpEF (n=9) and hypertrophic cardiomyopathy (HCM; n=14). We identified leucine-rich alpha-2-glycoprotein 1 (LRG1) as an aberrant protein across all three forms of HFpEF. We reported perturbations in signalling pathways in HFpEF mainly driven by complement/coagulation/protease and extracellular matrix (ECM) proteins, highlighting the haemostatic disturbances, notably platelet degranulation caused by systematically elevated platelet cytosolic Ca2+. We provided a publicly available online application (https://hao-chen-uts-99171821.shinyapps.io/HFpEF-Proteomics/) of our findings.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Matthew Padula

LAB HEAD: Lana McClements

PROVIDER: PXD024012 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	HFpEF_human_plasma_STAGETIPS_01.mgf	Mgf
	HFpEF_human_plasma_STAGETIPS_01.mzid.gz	Mzid
	HFpEF_human_plasma_STAGETIPS_01.raw	Raw
	HFpEF_human_plasma_STAGETIPS_02.mgf	Mgf
	HFpEF_human_plasma_STAGETIPS_02.mzid.gz	Mzid

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Publications

Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction.

Chen Hao H Tesic Milorad M Nikolic Valentina N VN Pavlovic Milan M Vucic Rada M RM Spasic Ana A Jovanovic Hristina H Jovanovic Ivana I Town Stephanie E L SEL Padula Matthew P MP McClements Lana L

Biomolecules 20221004 10

Heart failure with preserved ejection fraction (HFpEF) accounts for around 50% of all heart failure cases. It is a heterogeneous condition with poorly understood pathogenesis. Here, we aimed to identify unique pathogenic mechanisms in acute and chronic HFpEF and hypertrophic cardiomyopathy (HCM). We performed unbiased, comprehensive proteomic analyses of plasma samples from gender- and BMI-matched patients with acute HFpEF (n = 8), chronic HFpEF (n = 9) and HCM (n = 14) usin ...[more]

PMID: 36291628

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