Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Cell Culture
SUBMITTER: Jennifer Schwarz
LAB HEAD: Bettina Warscheid
PROVIDER: PXD024037 | Pride | 2022-02-16
REPOSITORIES: Pride
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MaxQuant_output.zip | Other | |||
QEplus010511.raw | Raw | |||
QEplus010512.raw | Raw | |||
QEplus010513.raw | Raw | |||
QEplus010514.raw | Raw |
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Life science alliance 20210915 11
B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. Here, we used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a protein tyrosine phosphatase profiling revealed a high expression of the protein tyrosine phosphatase 1B (PTP1B) in Ramos and human naïve B cells. The loss of PTP1B leads to increased B cell activati ...[more]