Dataset Information

Defining changes in the total levels of proteins upon RPN-6 RNAi

ABSTRACT: Here we defined changes in the total levels of individual proteins upon RPN-6 RNAi in young C. elegans adults (day 5)

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: David Vilchez

LAB HEAD: David Vilchez

PROVIDER: PXD024095 | Pride | 2021-05-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	1708.xlsx	Xlsx
	20190403_Q2_UC_ColID_776_ProjID_1708_Vilchez_Sample_1_Vector_RNAi_1.raw	Raw
	20190403_Q2_UC_ColID_776_ProjID_1708_Vilchez_Sample_2_Vector_RNAi_2.raw	Raw
	20190403_Q2_UC_ColID_776_ProjID_1708_Vilchez_Sample_3_Vector_RNAi_3.raw	Raw
	20190403_Q2_UC_ColID_776_ProjID_1708_Vilchez_Sample_4_RPN-6_RNAi_1.raw	Raw

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Publications

Rewiring of the ubiquitinated proteome determines ageing in C. elegans.

Koyuncu Seda S Loureiro Rute R Lee Hyun Ju HJ Wagle Prerana P Krueger Marcus M Vilchez David D

Nature 20210728 7871

Ageing is driven by a loss of cellular integrity<sup>1</sup>. Given the major role of ubiquitin modifications in cell function<sup>2</sup>, here we assess the link between ubiquitination and ageing by quantifying whole-proteome ubiquitin signatures in Caenorhabditis elegans. We find a remodelling of the ubiquitinated proteome during ageing, which is ameliorated by longevity paradigms such as dietary restriction and reduced insulin signalling. Notably, ageing causes a global loss of ubiquitinatio ...[more]

PMID: 34321666

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