Dataset Information
Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Neuroendocrine Tumor Cell
DISEASE(S): Neuroendocrine Tumor
SUBMITTER: 
Sharon Gorski
LAB HEAD: Sharon Gorski
PROVIDER: PXD024175 | Pride | 2021-11-30
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Layout.xlsx | Xlsx | |||
| Set1_1.raw | Raw | |||
| Set1_10.raw | Raw | |||
| Set1_11.raw | Raw | |||
| Set1_12.raw | Raw |
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Publications
Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms.
Cell reports 20211001 2
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors underlying this heterogeneity. Transcriptomic analysis of 84 PNEN specimens, drawn from two cohorts, is substantiated with proteomic profiling and identifies four subgroups: Proliferative, PDX1-high, Alpha cell-like and Stromal/Mesenchymal. The Proliferative subgroup, consisting of both well- and poorly differentiated specimens, is associ ...[more]
