Proteomics

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Proteome and phosphoproteome analyses reveal the kinase regulatory network involved in glycogen synthesis kinase 3β


ABSTRACT: To analyze the roles of GSK-3β in podocytes, GSK-3β knockdown lentivirus by Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9 was applied to establish stable cell lines. Phosphoproteome and proteome evaluation was conducted using TMT labeled LC-MS/MS technologies.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

SUBMITTER: Mingyang Hu  

LAB HEAD: Sijie Zhou

PROVIDER: PXD024543 | Pride | 2021-09-10

REPOSITORIES: Pride

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Publications

Proteome and Phosphoproteome Analyses Reveal the Kinase Regulatory Network Involved in Glycogen Synthesis Kinase 3β.

Hu Mingyang M   Fang Jiuyuan J   Wang Huijuan H   Zhou Sijie S  

Frontiers in genetics 20210407


Diabetic nephropathy is the most common chronic kidney disease in the world and the main cause of end-stage renal disease (ESRD). The structural integrity of podocytes is fundamental to the normal function of the glomerulus, and the role of glycogen synthase kinase 3β (GSK-3β) in podocytes is complicated. A thorough understanding of GSK-3β is crucial to understand the mechanism of diabetic nephropathy. To analyze the roles of GSK-3β in podocytes, GSK-3β knockdown lentivirus by clustered regularl  ...[more]

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