Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Sadhna Phanse
LAB HEAD: Mohan Babu
PROVIDER: PXD024695 | Pride | 2021-09-10
REPOSITORIES: pride
Nucleic acids research 20210801 14
The yeast cyclic AMP-dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits remains inconclusive. Here, we report that deleting the tpk1 catalytic subunit reduces non-homologous end joining (NHEJ) efficiency, whereas tpk2-3 and bcy1 deletion does not. Epistatic analyses revealed ...[more]