Proteomics

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A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy

ABSTRACT: There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unclear. Here, we hypothesized that identifying human brain proteome from serial CTE stages (CTE I-IV) would provide critical new insights into CTE pathogenesis. Brain samples from frontotemporal lobar degeneration due to microtubule associated protein tau (FTLD-MAPT) mutations were also included as a distinct tauopathy phenotype for comparison.

INSTRUMENT(S): Orbitrap Fusion Lumos, Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Duc Duong  

LAB HEAD: Chadwick Hales, MD, PhD

PROVIDER: PXD024724 | Pride | 2021-09-10

REPOSITORIES: Pride

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HUMAN_ABETA4ISO.fasta Fasta
checksum.txt Txt
cxhales_b3_tmt_.pdResult Other
cxhales_b3_tmt_01.raw Raw
cxhales_b3_tmt_02.raw Raw
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A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy.

Gutierrez-Quiceno Laura L   Dammer Eric B EB   Johnson Ashlyn Grace AG   Webster James A JA   Shah Rhythm R   Duong Duc D   Yin Luming L   Seyfried Nicholas T NT   Alvarez Victor E VE   Stein Thor D TD   McKee Ann C AC   Hales Chadwick M CM  

Molecular neurodegeneration 20210625 1

<h4>Background</h4>There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unclear. Here, we hypothesized that identifying the human brain proteome from serial CTE stages (CTE I-IV) would provide critical new insights into CTE pathogenesis. Brain samples from frontotemporal loba  ...[more]

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