Proteomics

Dataset Information

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ANALYSIS OF NETWORKS IN THE DORSOLATERAL PREFRONTAL CORTEX IN CHRONIC SCHIZOPHRENIA: RELEVANCE OF ALTERED IMMUNE RESPONSE


ABSTRACT: The dorsolateral prefrontal cortex (DLPFC) is the association area in the anterior part of the frontal lobe and has a crucial role in cognitive functioning and negative symptoms in SZschizophrenia. However, limited information of altered protein networks is available in this region in schizophrenia. We performed a proteomic analysis using single-shot liquid chromatography-tandem mass spectrometry of grey matter of postmortem DLPFC in chronic schizophrenia subjects (n=20) and healthy individuals (n=20) followed by bioinformatic analysis to identify altered protein networks in SZ.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Ricard Rodriguez-Mias  

LAB HEAD: Judit Villen

PROVIDER: PXD024939 | Pride | 2023-05-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Oxidation__M_Sites.txt Txt
allPeptides.txt Txt
checksum.txt Txt
evidence.txt Txt
experimentalDesignTemplate.txt Txt
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Publications

Analysis of networks in the dorsolateral prefrontal cortex in chronic schizophrenia: Relevance of altered immune response.

Vera-Montecinos América A   Rodríguez-Mias Ricard R   Vila Èlia È   Villén Judit J   Ramos Belén B  

Frontiers in pharmacology 20230323


The dorsolateral prefrontal cortex (DLPFC) has a crucial role in cognitive functioning and negative symptoms in schizophrenia. However, limited information of altered protein networks is available in this region in schizophrenia. We performed a proteomic analysis using single-shot liquid chromatography-tandem mass spectrometry of grey matter of postmortem DLPFC in chronic schizophrenia subjects (n = 20) and unaffected subjects (n = 20) followed by bioinformatic analysis to identify altered prote  ...[more]

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