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The extracellular matrix landscape identifies different etiologies behind bicuspid and tricuspid aortic valve degeneration

ABSTRACT: The molecular basis of aortic valve degeneration (AVD) is unclear. The extracellular matrix (ECM) of the valve is in dynamic reciprocity with its surrounding microenvironment and contains molecular traits of the pathophysiological processes. We compared abundances of ECM proteins from excised valve tissues of 88 patients with isolated AVD of normal tricuspid (TAV) and congenital bicuspid aortic valves (BAV) by employing a new method for protein preparation and quantitative mass-spectrometry analysis.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart, Extracellular Matrix Organization

DISEASE(S): Aortic Valve Disease

SUBMITTER: Christian Beusch

LAB HEAD: Sergey Rodin

PROVIDER: PXD025002 | Pride | 2023-09-03

REPOSITORIES: Pride

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			Action	DRS
	20190912_ECM_PatNr_002.raw	Raw
	20190912_ECM_PatNr_003.raw	Raw
	20190912_ECM_PatNr_005.raw	Raw
	20190912_ECM_PatNr_006.raw	Raw
	20190912_ECM_PatNr_008.raw	Raw

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