Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mycobacteroides Abscessus Subsp. Abscessus
SUBMITTER: Unnati Chauhan
LAB HEAD: Nancy Woychik
PROVIDER: PXD025047 | Pride | 2023-07-20
REPOSITORIES: Pride
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Troian Eduardo A EA Maldonado Heather M HM Chauhan Unnati U Barth Valdir C VC Woychik Nancy A NA
Nature communications 20230622 1
Mycobacterium abscessus (Mab) infections are inexplicably intractable to clearing after aggressive and lengthy treatment regimens. Here we discovered that acquisition of a single toxin-antitoxin system enables Mab to activate a phenotypic switch that enhances survival upon treatment with current first-line antibiotics. This switch is tripped when the VapC5 toxin inactivates tRNA<sup>SerCGA</sup> by cleavage at only one site within its anticodon, leading to growth arrest. Concomitant tRNA<sup>Ser ...[more]