Proteomics

Dataset Information

0

Analysis of Pancreatic Extracellular Matrix Protein Post-Translational Modifications via Electrostatic Repulsion-Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry

ABSTRACT: The pancreas is a vital organ with digestive and endocrine roles, and diseases of the pancreas affect millions of people yearly. A better understanding of the pancreas proteome and its dynamic post-translational modifications (PTMs) is necessary to engineer higher fidelity tissue analogues for use in transplantation. The extracellular matrix (ECM) has major roles in binding and signaling essential to the viability of insulin-producing islets of Langerhans. To analyze post-translational modifications (PTMs) in the pancreas, native and decellularized tissues from four donors were analyzed.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Pancreas

SUBMITTER: Dylan Nicholas Tabang  

LAB HEAD: Lingjun Li

PROVIDER: PXD025048 | Pride | 2021-08-06

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
02132021_Panc_ERLIC_AllFracsS_20.msf Msf
02132021_Panc_ERLIC_AllFracs_S21.msf Msf
02132021_Panc_ERLIC_AllFracs_S22.msf Msf
02132021_Panc_ERLIC_AllFracs_S24.msf Msf
02152021_ERLIC_PTM_panc_ratio_PSMs.txt Txt
Items per page:
1 - 5 of 74
altmetric image

Publications

Analysis of pancreatic extracellular matrix protein post-translational modifications <i>via</i> electrostatic repulsion-hydrophilic interaction chromatography coupled with mass spectrometry.

Tabang Dylan Nicholas DN   Cui Yusi Y   Tremmel Daniel M DM   Ford Megan M   Li Zihui Z   Sackett Sara Dutton SD   Odorico Jon S JS   Li Lingjun L  

Molecular omics 20211011 5

The pancreas is a vital organ with digestive and endocrine roles, and diseases of the pancreas affect millions of people yearly. A better understanding of the pancreas proteome and its dynamic post-translational modifications (PTMs) is necessary to engineer higher fidelity tissue analogues for use in transplantation. The extracellular matrix (ECM) has major roles in binding and signaling essential to the viability of insulin-producing islets of Langerhans. To characterize PTMs in the pancreas, n  ...[more]

Similar Datasets

Proteomics Counterion Optimization Dramatically Improves Selectivity for Phosphopeptides and Glycopeptides in Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC)
2021-06-01 | PXD022988 | Pride
Proteomics SARS-CoV-2 spike protein glycosylation enriched by HILIC and Ti-IMAC
2022-01-11 | PXD026450 | Pride
Proteomics Finding the Sweet Spot in ERLIC Mobile Phase for Simultaneous Enrichment of N-Glyco and Phosphopeptides
2019-09-06 | PXD015179 | Pride
Proteomics Boost-DiLeu: Enhanced Isobaric N,N-Dimethyl Leucine Tagging Strategy for Comprehensive Quantitative Glycoproteomic Analysis
2022-09-08 | PXD029269 | Pride
Proteomics ATP-Coated Dual-functionalized Titanium (IV) IMAC Material for Simultaneous Enrichment and Separation of Glycopeptides and Phosphopeptides
2023-07-20 | PXD029775 | Pride
Proteomics An optimized glycopeptide enrichment method – it’s all about the sauce
2022-06-29 | PXD031177 | Pride
Proteomics Glycan shield of the ebolavirus envelope glycoprotein GP
2022-08-02 | PXD031459 | Pride
Proteomics Allotype-specific glycosylation and cellular localization of HLA class I proteins
2022-02-17 | PXD023684 | Pride
Proteomics Glycoproteomics profiling of recombinant SARS-CoV-2 stabilized Spike construct
2021-07-28 | PXD025554 | Pride
Proteomics Urinary glycopeptide analysis for the investigation of novel biomarkers
2018-11-29 | PXD011214 | Pride