Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: Sarah Welsh
LAB HEAD: Alessandro Gardini
PROVIDER: PXD025060 | Pride | 2022-08-12
REPOSITORIES: pride
Action | DRS | |||
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GardiniA-18-G252-GelControl-HF.raw | Raw | |||
GardiniA-18-G252-PP2CA-HF.raw | Raw | |||
GardiniA-19-G011-Gelcontrol-HF.raw | Raw | |||
GardiniA-19-G011-PP2CA-HF.raw | Raw | |||
GardiniA-19-G011-proteinGroups.xlsx | Xlsx |
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Vervoort Stephin J SJ Welsh Sarah A SA Devlin Jennifer R JR Barbieri Elisa E Knight Deborah A DA Offley Sarah S Bjelosevic Stefan S Costacurta Matteo M Todorovski Izabela I Kearney Conor J CJ Sandow Jarrod J JJ Fan Zheng Z Blyth Benjamin B McLeod Victoria V Vissers Joseph H A JHA Pavic Karolina K Martin Ben P BP Gregory Gareth G Demosthenous Elena E Zethoven Magnus M Kong Isabella Y IY Hawkins Edwin D ED Hogg Simon J SJ Kelly Madison J MJ Newbold Andrea A Simpson Kaylene J KJ Kauko Otto O Harvey Kieran F KF Ohlmeyer Michael M Westermarck Jukka J Gray Nathanael N Gardini Alessandro A Johnstone Ricky W RW
Cell 20210517 12
Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing checkpoint following transcription initiation is primarily controlled by CDK9. We discovered that CDK9-mediated, RNAPII-driven transcription is functionally opposed by a protein phosphatase 2A (PP2A) complex that is recruited to transcription sites by the Integrator complex subunit INTS6. PP2A dynamically antagonizes phosphoryl ...[more]