Proteomics

Dataset Information

0

Furan warheads for covalent trapping of weak protein-protein interactions: specific cross-linking of thymosin β4 to actin


ABSTRACT: We describe furan as a triggerable ‘warhead’ for site-specific cross-linking using the actin and thymosin β4 (Tβ4)-complex as model of a weak and dynamic protein-protein interaction with known 3D structure and with application potential in disease contexts. The presented in vitro validation of covalently acting ‘furan-armed’ Tβ4-variants provides initial proof to further exploit furan-technology for covalent drug design.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Oryctolagus Sp. 'rabbit_od'

SUBMITTER: Marina Gay  

LAB HEAD: Annemieke Madder

PROVIDER: PXD025066 | Pride | 2021-05-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
3690_LM_C4H2O2_TrypAspN_Xi1.7.6.1.mzid.gz Mzid
3690_LM_C4H2O2_TrypChymo_Xi1.7.6.1.mzid.gz Mzid
3690_LM_Control_TrypAspN.mgf Mgf
3690_LM_Control_TrypChymo.mgf Mgf
3690_LM_XL_Ac_trypAspN.raw Raw
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