Supermeres, a new functional extracellular nanoparticle replete with disease biomarkers and therapeutic target
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ABSTRACT: Extracellular vesicles, including exosomes, and exomere nanoparticles, are under intense investigation for cargo that may serve as clinical biomarkers or therapeutic targets. Here, we report discovery of a new extracellular nanoparticle, termed supermeres. We performed LC/MS-MS proteomics analyses on gradient-purified sEVs, NVs, exomeres and supermeres. The proteomic profile of supermeres is clearly distinct from that of sEVs, NVs and exomeres This study identifies a new functional nanoparticle replete with potential circulating biomarkers and therapeutic targets that can be exploited for clinical benefit in a host of diseases.
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Colon Epithelial Cell
DISEASE(S): Colorectal Cancer
SUBMITTER: Kristie Lindsey Rose
LAB HEAD: Kristie Lindsey Rose
PROVIDER: PXD025213 | Pride | 2021-11-02
REPOSITORIES: Pride
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