Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Neuron
SUBMITTER: Phillip Wilmarth
LAB HEAD: Michael S. Cohen
PROVIDER: PXD025386 | Pride | 2021-07-21
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
BP6_P2A_GFP_sprot_2016.06_rat_both.fasta | Fasta | |||
COH_BP6_1.raw | Raw | |||
COH_BP6_1_filtered.ms2 | Other | |||
COH_BP6_1_filtered.sqt | Other | |||
COH_BP6_1_filtered.txt | Txt |
Items per page: 1 - 5 of 21 |
Cells 20210522 6
PARP6, a member of a family of enzymes (17 in humans) known as poly-ADP-ribose polymerases (PARPs), is a neuronally enriched PARP. While previous studies from our group show that Parp6 is a regulator of dendrite morphogenesis in rat hippocampal neurons, its function in the nervous system in vivo is poorly understood. Here, we describe the generation of a <i>Parp6</i> loss-of-function mouse model for examining the function of Parp6 during neurodevelopment in vivo. Using CRISPR-Cas9 mutagenesis, w ...[more]