Proteomics

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Proteomic analysis of membrane vesicles from clinical Cutibacterium acnes isolates


ABSTRACT: Recently the membrane vesicles (MVs) production has been observed in Gram-positive bacterium, Cutibacterium acnes (C. acnes). In order to explore the mechanism of antibiotic resistance and the virulent components within the C. acnes-derived MVs, we isolated MVs from the clinical C. acnes, which were sensitive or resistant to antibiotics erythromycin and clindamycin. With the LC-MS/MS method, we detected several lipases, virulent factors and cell division protein differentially expressed between the sensitive and the resistant C. acnes-derived MVs.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Cutibacterium Acnes Sk137

TISSUE(S): Cell Culture

SUBMITTER: Min Jiang  

LAB HEAD: Ying Ma

PROVIDER: PXD025460 | Pride | 2022-05-20

REPOSITORIES: Pride

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Publications

Comparative Proteomic Analysis of Membrane Vesicles from Clinical <i>C. acnes</i> Isolates with Differential Antibiotic Resistance.

Jiang Min M   Fan Xiaoyao X   Jiang Ziqi Z   Chen Huyan H   Liu Ye Y   Yu Tianze T   Huang Qiong Q   Ma Ying Y  

Clinical, cosmetic and investigational dermatology 20220417


<h4>Purpose</h4><i>Cutibacterium acnes</i> (<i>C. acnes</i>) is closely associated with the pathogenesis of acne, and antibiotics targeting <i>C. acnes</i> have been widely used for decades. However, antibiotic resistance has been increasing rapidly. Membrane vesicles (MVs) have been found to play important roles in antibiotic resistance in some bacteria. We aimed to explore the mechanism of antibiotic resistance and the virulence components within <i>C. acnes</i>-derived MVs.<h4>Materials and m  ...[more]

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