Proteomics

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C. elegans provide "milk" for their young

ABSTRACT: The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signaling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-reproductive animals continues, supported by destructive repurposing of intestinal biomass that contributes to senescence. Post-reproductive mothers vent this yolk which can be consumed by larvae and promotes their growth. This implies that later yolk production is not futile; instead vented yolk functions similarly to milk. Moreover, yolk venting is promoted by IIS. That this process is promoted by IIS provides new insights into how and why IIS shortens lifespan in C. elegans. Fully-fed d4 hermaphrodites were allowed to vent for 30 min, and vented proteins analysed against excretory/secretory products collected for L3 larvae as a negative control.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Milk

DISEASE(S): Breast Cancer

SUBMITTER: Graham Taylor  

LAB HEAD: Graham W Taylor

PROVIDER: PXD025472 | Pride | 2022-02-17

REPOSITORIES: Pride

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C. elegans feed yolk to their young in a form of primitive lactation.

Kern Carina C CC   Townsend StJohn S   Salzmann Antoine A   Rendell Nigel B NB   Taylor Graham W GW   Comisel Ruxandra M RM   Foukas Lazaros C LC   Bähler Jürg J   Gems David D  

Nature communications 20211005 1

The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signalling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-reproductive animals continues in an apparently futile fashion, supported by destructive repurposing of intestinal biomass that contributes to senescence. Here we show that post-reproductive mothers vent yolk which can be consumed by larvae and promo  ...[more]

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