Proteomics

Dataset Information

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Hyperphosphorylation of sarcomeric proteins in heart failure with preserved ejection fraction: selective reversal of PKC hyperactivity by cell therapy

ABSTRACT: Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca2+-sensitivity and mechanosensing. Treatment with cardiosphere-derived cells (CDCs) restores normal diastolic function, attenuates fibrosis and inflammation, and improves survival in a rat HFpEF model. Here, we quantified the phosphorylation changes that underlie HFpEF and those reversed by CDC therapy, with a focus on the sarcomeric subproteome.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart, Heart Left Ventricle

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Vidya Venkatraman  

LAB HEAD: Dr. Jennifer Van Eyk

PROVIDER: PXD025555 | Pride | 2022-04-23

REPOSITORIES: Pride

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Publications

Myofilament Phosphorylation in Stem Cell Treated Diastolic Heart Failure.

Soetkamp Daniel D   Gallet Romain R   Parker Sarah J SJ   Holewinski Ronald R   Venkatraman Vidya V   Peck Kiel K   Goldhaber Joshua I JI   Marbán Eduardo E   Van Eyk Jennifer E JE  

Circulation research 20211013 12

<h4>Rationale</h4>Phosphorylation of sarcomeric proteins has been implicated in heart failure with preserved ejection fraction (HFpEF); such changes may contribute to diastolic dysfunction by altering contractility, cardiac stiffness, Ca<sup>2+</sup>-sensitivity, and mechanosensing. Treatment with cardiosphere-derived cells (CDCs) restores normal diastolic function, attenuates fibrosis and inflammation, and improves survival in a rat HFpEF model.<h4>Objective</h4>Phosphorylation changes that und  ...[more]

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