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Dietary fiber deficiency promotes cognitive impairment through the gut-hippocampal axis

ABSTRACT: C57BL/6J male mice (11 weeks old) were randomly divided into two groups fed either the control (Con) diet (LabDiet 5010) or fiber deficiency (FD) diet for 15 weeks.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Xing Ge

LAB HEAD: Yinghua Yu

PROVIDER: PXD025638 | Pride | 2022-02-17

REPOSITORIES: Pride

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			Action	DRS
	S9050TQ_1_Slot2-14_1_296.d.rar	Other
	S9050TQ_2_Slot2-15_1_297.d.zip	Other
	S9050TQ_3_Slot2-16_1_298.d.rar	Other
	S9050TQ_4_Slot2-17_1_299.d.zip	Other
	S9050TQ_5_Slot2-18_1_300.d.rar	Other

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Publications

A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites.

Shi Hongli H Ge Xing X Ma Xi X Zheng Mingxuan M Cui Xiaoying X Pan Wei W Zheng Peng P Yang Xiaoying X Zhang Peng P Hu Minmin M Hu Tao T Tang Renxian R Zheng Kuiyang K Huang Xu-Feng XF Yu Yinghua Y

Microbiome 20211111 1

<h4>Background</h4>Cognitive impairment, an increasing mental health issue, is a core feature of the aging brain and neurodegenerative diseases. Industrialized nations especially, have experienced a marked decrease in dietary fiber intake, but the potential mechanism linking low fiber intake and cognitive impairment is poorly understood. Emerging research reported that the diversity of gut microbiota in Western populations is significantly reduced. However, it is unknown whether a fiber-deficien ...[more]

PMID: 34758889

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Low paternal dietary folate alters the sperm epigenome and is associated with negative pregnancy outcomes

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