Sulforaphane suppresses metastasis of breast cancer cells by targeting RAF/MEK/ERK pathway to inhibit actin stress fiber formation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Breast Cancer Cell
DISEASE(S): Breast Cancer
SUBMITTER: 
Jing Liu
LAB HEAD: Jing Liu
PROVIDER: PXD025639 | Pride | 2022-05-20
REPOSITORIES: Pride
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Publications
Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway.
Zhang Ying Y Lu Qian Q Li Nan N Xu Ming M Miyamoto Tatsuo T Liu Jing J
NPJ breast cancer 20220324 1
Breast cancer metastasis is the main cause of cancer death in women, so far, no effective treatment has inhibited breast cancer metastasis. Sulforaphane (SFN), a natural compound derived from broccoli, has shown potential health benefits in many cancers. However, research on breast cancer metastasis is still insufficient. Here, we showed that SFN, including its two isomers of R-SFN and S-SFN, significantly inhibited TGF-β1-induced migration and invasion in breast cancer cells. Proteomic and phos ...[more]
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