Proteomics

Dataset Information

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Sulforaphane suppresses metastasis of breast cancer cells by targeting RAF/MEK/ERK pathway to inhibit actin stress fiber formation


ABSTRACT: SFN, including its two isomers of R-SFN and S-SFN, significantly inhibited TGF-1-induced migration and invasion in MDA-MB-231 cells. Proteomic and phosphoproteomic analysis showed that SFN affected the formation of cytoskeleton. Subsequent experiments confirmed that SFN significantly inhibited TGF-1-induced actin stress fiber formation and the expression of actin stress fiber formation-associated proteins, including paxillin, IQGAP1, FAK, PAK2, and ROCK.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Breast Cancer Cell

DISEASE(S): Breast Cancer

SUBMITTER: Jing Liu  

LAB HEAD: Jing Liu

PROVIDER: PXD025639 | Pride | 2022-05-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20190928_231_SFN_control_nor_1.raw Raw
20190928_231_SFN_control_nor_2.raw Raw
20190928_231_SFN_control_nor_3.raw Raw
20190928_231_SFN_control_phos_1.raw Raw
20190928_231_SFN_control_phos_2.raw Raw
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Publications

Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway.

Zhang Ying Y   Lu Qian Q   Li Nan N   Xu Ming M   Miyamoto Tatsuo T   Liu Jing J  

NPJ breast cancer 20220324 1


Breast cancer metastasis is the main cause of cancer death in women, so far, no effective treatment has inhibited breast cancer metastasis. Sulforaphane (SFN), a natural compound derived from broccoli, has shown potential health benefits in many cancers. However, research on breast cancer metastasis is still insufficient. Here, we showed that SFN, including its two isomers of R-SFN and S-SFN, significantly inhibited TGF-β1-induced migration and invasion in breast cancer cells. Proteomic and phos  ...[more]

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