Dataset Information

Human salivary extracellular vesicles LC-MS/MS

ABSTRACT: This study aims at the quantitative analysis of human salivary extracellular vesicle (EV) content from patients affected by primary Sjogren's syndrome (pSS) in order to determine candidate biomarkers for disease diagnosis, patient stratification and monitoring.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Saliva

DISEASE(S): Sjogren's Syndrome

SUBMITTER: Francesco Finamore

LAB HEAD: Francesco Finamore

PROVIDER: PXD025649 | Pride | 2021-06-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	2018_08_27_Pool_EVs_WS_pSS_R1.tandem.pep.xml	Pepxml
	2018_08_27_Pool_EVs_WS_pSS_R1.wiff	Wiff
	2018_08_27_Pool_EVs_WS_pSS_R2.tandem.pep.xml	Pepxml
	2018_08_27_Pool_EVs_WS_pSS_R2.wiff	Wiff
	2018_08_27_Pool_EVs_WS_pSS_R3.tandem.pep.xml	Pepxml

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Publications

Characterization of Extracellular Vesicle Cargo in Sjögren's Syndrome through a SWATH-MS Proteomics Approach.

Finamore Francesco F Cecchettini Antonella A Ceccherini Elisa E Signore Giovanni G Ferro Francesco F Rocchiccioli Silvia S Baldini Chiara C

International journal of molecular sciences 20210504 9

Primary Sjögren's syndrome (pSS) is a complex heterogeneous disease characterized by a wide spectrum of glandular and extra-glandular manifestations. In this pilot study, a SWATH-MS approach was used to monitor extracellular vesicles-enriched saliva (EVs) sub-proteome in pSS patients, to compare it with whole saliva (WS) proteome, and assess differential expressed proteins between pSS and healthy control EVs samples. Comparison between EVs and WS led to the characterization of compartment-specif ...[more]

PMID: 34064456

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