Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
DISEASE(S): Non-alcoholic Steatohepatitis
SUBMITTER: Michele Puglia
LAB HEAD: Blagoy Blagoev
PROVIDER: PXD025691 | Pride | 2021-07-13
REPOSITORIES: Pride
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120421_FP_AnneLoft_CTR_1.raw | Raw | |||
120421_FP_AnneLoft_CTR_2.raw | Raw | |||
120421_FP_AnneLoft_CTR_3.raw | Raw | |||
120421_FP_AnneLoft_CTR_4.raw | Raw | |||
120421_FP_AnneLoft_NASH_1.raw | Raw |
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Cell metabolism 20210707 8
Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-associated fatty liver disease; yet, the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatohepatitis (NASH) and liver fibrosis are incompletely understood. Using cell-type-resolved genomics, we show that comprehensive alterations in hepatocyte genomic and transcriptional settings during NASH progression, led to a loss of hepatocyte identity ...[more]