Dataset Information

Proteomic characterization of human hepatocellular carcinoma (HCC) tumor biopsies

ABSTRACT: We analyzed the proteome of tumor and matched non-tumor biopsies from 51 treatment-naive Hepatocellular carcinoma (HCC) patients by DIA (SWATH). Thereby we aim to find subgroups of patients characterized by specific pathway activation. Furthermore, we aim to find novel factors involved in HCC development and novel biomarkers.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Hepatocellular Carcinoma

SUBMITTER: Eva Dazert

LAB HEAD: Prof. Mike Hall

PROVIDER: PXD025705 | Pride | 2022-03-14

REPOSITORIES: Pride

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Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages.

Ng Charlotte K Y CKY Dazert Eva E Boldanova Tuyana T Coto-Llerena Mairene M Nuciforo Sandro S Ercan Caner C Suslov Aleksei A Meier Marie-Anne MA Bock Thomas T Schmidt Alexander A Ketterer Sylvia S Wang Xueya X Wieland Stefan S Matter Matthias S MS Colombi Marco M Piscuoglio Salvatore S Terracciano Luigi M LM Hall Michael N MN Heim Markus H MH

Nature communications 20220504 1

Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs across clinical stages and etiologies. Pathways related to cell cycle, transcriptional and translational control, signaling transduction, and metabolism are dysregulated and differentially regulated on the genomic, transcriptomic, proteomic and phosphoproteomic levels. We describe candidate copy number-driven driver genes involve ...[more]

PMID: 35508466

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