Proteomics

Dataset Information

0

Macaca fascicularis liver LC-MS/MS


ABSTRACT: In order to develop new safe and potent therapeutics, insights into the mechanisms underlying diabetes mellitus are urgently needed. We used proteomics profiling of the liver tissue from Macaca fascicularis with spontaneously occurred diabetes mellitus at their middle age and including two groups of the monkeys fed with the same food and high-fat and high-sugar diet for comparison.We hoped to find something new for diabetes mellitus treatment.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Macaca Fascicularis (crab-eating Macaque) (cynomolgus Monkey)

TISSUE(S): Liver

SUBMITTER: Dianqiang Yang  

LAB HEAD: Shuhai Lin

PROVIDER: PXD025863 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HFHS_1_Slot1-7_1_7881.d.zip Other
HFHS_2_Slot1-8_1_7882.d.zip Other
HFHS_3_Slot1-9_1_7883.d.zip Other
NC_1_Slot1-4_1_7877.d.zip Other
NC_2_Slot1-5_1_7878.d.zip Other
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Publications

Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models.

Yang Zhu Z   Yang Dianqiang D   Tan Fancheng F   Wong Chi Wai CW   Yang James Y JY   Zhou Da D   Cai Zongwei Z   Lin Shu-Hai SH  

Frontiers in pharmacology 20211122


The prevalence of diabetes mellitus has been increasing for decades worldwide. To develop safe and potent therapeutics, animal models contribute a lot to the studies of the mechanisms underlying its pathogenesis. Dietary induction using is a well-accepted protocol in generating insulin resistance and diabetes models. In the present study, we reported the multi-omics profiling of the liver and sera from both peripheral blood and hepatic portal vein blood from <i>Macaca fascicularis</i> that spont  ...[more]

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