Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Ovidio Jimenez Martin
LAB HEAD: Manfred Gessler
PROVIDER: PXD025996 | Pride | 2022-02-17
REPOSITORIES: Pride
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Jiménez Martín Ovidio O Schlosser Andreas A Furtwängler Rhoikos R Wegert Jenny J Gessler Manfred M
Cancer cell international 20211024 1
<h4>Background</h4>Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. MYCN encodes a transcription factor that requires dimerization with MAX to activate transcription of numerous target genes. MYCN gain has been associated with adverse prognosis in different childhood tumors including WT. The MYCN P44L and MAX R60Q mutations, located in either the transactivating or basic helix-loop-h ...[more]