Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast
DISEASE(S): Breast Cancer
SUBMITTER: Alex von kriegsheim
LAB HEAD: Eric o' Neill
PROVIDER: PXD026226 | Pride | 2021-10-07
REPOSITORIES: Pride
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The EMBO journal 20210917 20
Cell plasticity is a crucial hallmark leading to cancer metastasis. Upregulation of Rho/ROCK pathway drives actomyosin contractility, protrusive forces, and contributes to the occurrence of highly invasive amoeboid cells in tumors. Cancer stem cells are similarly associated with metastasis, but how these populations arise in tumors is not fully understood. Here, we show that the novel oncogene RASSF1C drives mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mech ...[more]