Dataset Information
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human) Severe Acute Respiratory Syndrome Coronavirus 2
TISSUE(S): Lung, Epithelial Cell
SUBMITTER: 
Mehdi Bouhaddou
LAB HEAD: Nevan J. Krogan
PROVIDER: PXD026302 | Pride | 2022-01-20
REPOSITORIES: Pride
Dataset's files
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Publications
Evolution of enhanced innate immune evasion by SARS-CoV-2.
Nature 20211223 7897
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission<sup>1,2</sup>. Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of spike are likely to contribute to adaptation. Here, using unbiased abundance proteomics, phosphoproteomics, RNA sequencing and viral replication assays, we show that isolates of the Alpha (B.1.1.7) variant<sup>3</sup> suppress innate immu ...[more]