Dataset Information

Utilizing of quantitative proteomics to identify species-specific protein therapeutic target for treatment of leishmaniasis.

ABSTRACT: Identification of common Leishmania antigen proteins is important for practical purposes ranging from diagnostic to the development of a vaccine for the prevention of leishmaniasis. Moreover, we need to establish the potential drug targets that interrupt the replication and transmission of the pathogen to promote drug discovery. Therefore, the objective of this work was to provide the public proteome database which would be useful for the establishment of novel protein antigenicity for therapeutic purposes. This information would introduce the alternative protein targets for Leishmaniasis, allowing the development of therapeutic strategies for the disease.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Leishmania Donovani Ld 2001

TISSUE(S): Cell Culture, Diploid Cell

DISEASE(S): Leishmaniasis

SUBMITTER: Sucheewin Krobthong

LAB HEAD: Kiattawee Choowongkomon

PROVIDER: PXD026304 | Pride | 2022-05-20

REPOSITORIES: Pride

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Utilizing Quantitative Proteomics to Identify Species-Specific Protein Therapeutic Targets for the Treatment of Leishmaniasis.

Krobthong Sucheewin S Yingchutrakul Yodying Y Samutrtai Pawitrabhorn P Hitakarun Atitaya A Siripattanapipong Suradej S Leelayoova Saovanee S Mungthin Mathirut M Choowongkomon Kiattawee K

ACS omega 20220404 15

Leishmaniasis is a tropical disease caused by Leishmania parasites, which are transmitted through the bites of infected sandflies. We focused on the emergence of leishmaniasis in Thailand caused by a species (Leishmania orientalis). Treatment by chemotherapy is not effective against L. orientalis. Hence, we intended to solve this issue using a proteomics approach to investigate protein profiles and in silico analysis for the identification of antigenic proteins from < ...[more]

PMID: 35474788

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