Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma, Blood
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Majid Ghassemian
LAB HEAD: Geert W Schmid-Schönbein
PROVIDER: PXD026332 | Pride | 2022-02-14
REPOSITORIES: pride
Action | DRS | |||
---|---|---|---|---|
1_peptides_1_1_0.mgf | Mgf | |||
Serum2.csv | Csv | |||
Serum80.csv | Csv | |||
Serum80.mgf | Mgf | |||
Serum_01.raw | Raw |
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Courelli Vasiliki V Ahmad Alla A Ghassemian Majid M Pruitt Chris C Mills Paul J PJ Schmid-Schönbein Geert W GW
Cellular and molecular bioengineering 20210813 6
<h4>Introduction</h4>Heart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence shows that active digestive enzymes can leak out of the small intestine into the systemic circulation and cause cell dysfunctions and organ failure.<h4>Methods</h4>Accordingly, we investigated in morning fasting plasma of heart failure (HF) patients the presence of pancreatic trypsin, a major enzyme responsible for di ...[more]