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Omics score: 1000

Proteomics Profiling of mesenchymal stem cell-derived microvesicles

ABSTRACT: Recently, mesenchymal stem cells-derived microvesicles (MMVs) attract much attention as a strategy of cell-free treatment. In our study, we found that MMVs could improve the organ dysfunction during sepsis. To investigate the mechanism, we harvested MMVs from mesenchymal stem cells to perform proteomic analysis, and chondrocyte-derived microvesicles (CMVs) were used as a negative control, and PGC-1α overexpressed-MMVs were used as a positive control. A total of 5411 proteins were identified in this study, and differentially expressed (DE) proteins were further identified with a cut-off of absolute fold change >1.5 and a significance p-value <0.05. Compared with CMV group, 321 proteins were upregulated and 209 proteins were downregulated in MMVs. This study illustrated the differences between MMVs and CMVs, and provided a sight for investigating the protective effect of MMVs.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Mesenchymal Stem Cell

DISEASE(S): Not Available

SUBMITTER: Danyang Zheng

LAB HEAD: Danyang Zheng

PROVIDER: PXD026344 | Pride | 2021-06-08

REPOSITORIES: Pride

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			Action	DRS
	SA005LQ_CMV_1_Slot2-33_1_5669.d.zip	Other
	SA005LQ_CMV_2_Slot2-34_1_5670.d.zip	Other
	SA005LQ_CMV_3_Slot2-35_1_5671.d.zip	Other
	SA005LQ_MMV_1_Slot2-30_1_5665.d.zip	Other
	SA005LQ_MMV_2_Slot2-31_1_5666.d.zip	Other

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