Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Neutrophil, Blood
DISEASE(S): Acute Leukemia,Neuroblastoma
SUBMITTER: Hong Wang
LAB HEAD: Hong Wang
PROVIDER: PXD026454 | Pride | 2023-03-11
REPOSITORIES: Pride
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Neoplasia (New York, N.Y.) 20220223
Neuroblastoma accounts for 15% of cancer-related deaths in children, highlighting an unmet need for novel therapies. Selinexor is a small molecule inhibitor of XPO1. XPO1 shuffles cargo proteins with a nuclear export sequence from the nucleus to the cytosol, many of which are essential for cancer growth and cell maintenance. We systematically tested the effect of selinexor against neuroblastoma cells in vitro and in vivo and used an advanced proteomic and phosphoproteomic screening approach to i ...[more]