Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Escherichia Coli
SUBMITTER: Daniel Bak
LAB HEAD: Eranthie Weerapana
PROVIDER: PXD026488 | Pride | 2024-05-22
REPOSITORIES: Pride
Items per page: 1 - 5 of 306 |
Nature chemical biology 20230112 3
Iron-sulfur (Fe-S) clusters are ubiquitous metallocofactors involved in redox chemistry, radical generation and gene regulation. Common methods to monitor Fe-S clusters include spectroscopic analysis of purified proteins and autoradiographic visualization of radiolabeled iron distribution in proteomes. Here, we report a chemoproteomic strategy that monitors changes in the reactivity of Fe-S cysteine ligands to inform on Fe-S cluster occupancy. We highlight the utility of this platform in Escheri ...[more]