Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Astrocyte Of The Spinal Cord, Primary Cell
DISEASE(S): Amyotrophic Lateral Sclerosis
SUBMITTER: Roberto Stella
LAB HEAD: Alessandro Bertoli
PROVIDER: PXD026576 | Pride | 2022-02-17
REPOSITORIES: Pride
Items per page: 1 - 5 of 12 |
International journal of molecular sciences 20210629 13
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose pathophysiology is largely unknown. Despite the fact that motor neuron (MN) death is recognized as the key event in ALS, astrocytes dysfunctionalities and neuroinflammation were demonstrated to accompany and probably even drive MN loss. Nevertheless, the mechanisms priming astrocyte failure and hyperactivation are still obscure. In this work, altered pathways and molecules in ALS astrocytes were unveiled by inve ...[more]