Leucyl-tRNA synthetase is a tumor suppressor in breast cancer and enables tumor suppressive translation
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ABSTRACT: In this study, we identify leucyl-tRNA synthetase (LARS) as a breast tumor suppressor. To identify the mechanism underlying LARS-mediated breast tumor suppression, we conducted TMT-proteomics in PyMT mouse tumors with monoallelic genetic deletion of LARS in the mammary tumor compartment. The analyses implicate LARS as a regulator of leucine-rich protein translation resulting in downregulation of candidate leucine-rich tumor suppressor genes.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Soren Heissel
LAB HEAD: Sohail Tavazoie
PROVIDER: PXD026609 | Pride | 2022-01-10
REPOSITORIES: Pride
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