Comprehensive and systematic characterization of novel nanodrug conjugate based on multi-functionalized magnetic iron-nanoparticles conjugated with cisplatin derivative: From the chemistry to the animal model

ABSTRACT: Nanodrugs need a completely characterization by both chemically and biological point of view. As nanoparticles have evolved as multi-functional systems combining different custom anchorages, their pharmacological involvements require more comprehensive analysis. In this work, we present the design and synthesis of novel iron-NPs conjugated with a cisplatin derivate and their biological evaluation by quantitative proteomics approches. To decipher detailed insights related to the NP interactions with environment (as protein corona) and pharmacodynamics functionalities of the nanodrugs conjugates, LC-MS/MS analysis was perform to stablish protein profile. Biocompatibility and animal model provided complete insights of the potential of multifunctional iron NPs.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human) Bos Taurus (bovine) Oryctolagus Cuniculus (rabbit)

TISSUE(S): Blood Plasma, Caco-2 Cell, Jurkat Cell, T-lymphoblastic Leukemia Cell Line

SUBMITTER: Ángela-Patricia Hernández  

LAB HEAD: Manuel Fuentes García

PROVIDER: PXD026615 | Pride | 2022-08-12

REPOSITORIES: Pride