Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Stem Cell
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Ruth Huttenhain
LAB HEAD: Ruth Huttenhain
PROVIDER: PXD026638 | Pride | 2021-11-03
REPOSITORIES: Pride
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202011_uniprot_reviewed_mus_musculus.fasta | Fasta | |||
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Hota Swetansu K SK Rao Kavitha S KS Blair Andrew P AP Khalilimeybodi Ali A Hu Kevin M KM Thomas Reuben R So Kevin K Kameswaran Vasumathi V Xu Jiewei J Polacco Benjamin J BJ Desai Ravi V RV Chatterjee Nilanjana N Hsu Austin A Muncie Jonathon M JM Blotnick Aaron M AM Winchester Sarah A B SAB Weinberger Leor S LS Hüttenhain Ruth R Kathiriya Irfan S IS Krogan Nevan J NJ Saucerman Jeffrey J JJ Bruneau Benoit G BG
Nature 20220126 7895
Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization<sup>1,2</sup>. Canalization is essential for stabilizing cell fate, but the mechanisms that underlie robust canalization are unclear. Here we show that the BRG1/BRM-associated factor (BAF) chromatin-remodelling complex ATPase gene Brm safeguards cell identity during directed cardiogenesis of mouse embryonic stem cells. Despite the establishment of a well-differentiated precardiac ...[more]