Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Rattus Rattus (black Rat)
TISSUE(S): Cell Culture
SUBMITTER: Ann-Christine König
LAB HEAD: Hans Zischka
PROVIDER: PXD026695 | Pride | 2022-02-17
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 16 |
Kabiri Yaschar Y Fuhrmann Anna A Becker Anna A Jedermann Luisa L Eberhagen Carola C König Ann-Christine AC Silva Tiago Barros TB Borges Fernanda F Hauck Stefanie M SM Michalke Bernhard B Knolle Percy P Zischka Hans H
Frontiers in cell and developmental biology 20210920
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of <i>ALR</i> was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation defici ...[more]