Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Canis Lupus X Canis Lupus Familiaris
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: Karsten Boldt
LAB HEAD: Dr. Karsten Boldt
PROVIDER: PXD026698 | Pride | 2023-12-28
REPOSITORIES: Pride
Action | DRS | |||
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2020.12.02_Syt13_Mostafa_all_Syt13-TAP_in_2D.xlsx | Xlsx | |||
HOR1829-S16-A-2D-WT-1.raw | Raw | |||
HOR1829-S16-B-2D-WT-1.raw | Raw | |||
HOR1829-S17-A-2D-WT-2.raw | Raw | |||
HOR1829-S17-B-2D-WT-2.raw | Raw |
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Nature communications 20220804 1
During pancreas development endocrine cells leave the ductal epithelium to form the islets of Langerhans, but the morphogenetic mechanisms are incompletely understood. Here, we identify the Ca<sup>2+</sup>-independent atypical Synaptotagmin-13 (Syt13) as a key regulator of endocrine cell egression and islet formation. We detect specific upregulation of the Syt13 gene and encoded protein in endocrine precursors and the respective lineage during islet formation. The Syt13 protein is localized to t ...[more]