Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Cervix Carcinoma
SUBMITTER: Michael Tellier
LAB HEAD: Shona Murphy
PROVIDER: PXD026720 | Pride | 2022-08-22
REPOSITORIES: Pride
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EMBO reports 20220818 10
CDK9 is a kinase critical for the productive transcription of protein-coding genes by RNA polymerase II (pol II). As part of P-TEFb, CDK9 phosphorylates the carboxyl-terminal domain (CTD) of pol II and elongation factors, which allows pol II to elongate past the early elongation checkpoint (EEC) encountered soon after initiation. We show that, in addition to halting pol II at the EEC, loss of CDK9 activity causes premature termination of transcription across the last exon, loss of polyadenylatio ...[more]