Proteomics

Dataset Information

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Proteomic analysis of filaggrin insufficient keratinocytes and secreted exosomes.


ABSTRACT: Filaggrin (FLG) is a key structural protein expressed in epidermal keratinocytes. Mutations in the filaggrin gene (FLG) are strongly linked to atopic dermatitis (AD) and allergic inflammation occurring later in life at distant body locations in AD patients. Keratinocytes secrete exosomes, small, lipid-rich membrane vesicles to communicate with distant cells, including within the immune system. The FLG gene was silenced in the HaCaT keratinocyte cell line by shRNA delivered using a lentiviral vector. HaCaT cells transduced with scrambled shRNA were used as a control.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Keratinocyte

DISEASE(S): Atopic Dermatitis,Ichthyosis Vulgaris

SUBMITTER: Aleksandra Bogucka  

LAB HEAD: Paulina Czaplewska

PROVIDER: PXD026859 | Pride | 2022-08-12

REPOSITORIES: pride

Dataset's files

Source:
Action DRS
2020-07-02-Homo_sapiens_SP.fasta Fasta
Cells_shC1-S1.wiff Wiff
Cells_shC1-S1.wiff.scan Wiff
Cells_shC1-S2.wiff Wiff
Cells_shC1-S2.wiff.scan Wiff
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