Proteomics

Dataset Information

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Dynamic proteomics of mesenchymal stem cells in critical limb ischemia


ABSTRACT: Mutant MetRS in MSCs allows efficient and specific identification of dynamic cell proteomics in situ, which reflect the functions and adaptive changes of MSCs that may be leveraged to understand and improve stem cell therapy in critical limb ischemia

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle, Mesenchymal Cell

DISEASE(S): Limb Ischemia

SUBMITTER: Yipeng Du  

LAB HEAD: Zhiliang Li

PROVIDER: PXD026954 | Pride | 2021-09-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HLI_D1.raw Raw
HLI_D14.raw Raw
HLI_D3.raw Raw
HLI_D7.raw Raw
Sham_D1.raw Raw
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Publications

Deciphering the <i>in vivo</i> Dynamic Proteomics of Mesenchymal Stem Cells in Critical Limb Ischemia.

Du Yipeng Y   Li Xiaoting X   Yan Wenying W   Zeng Zhaohua Z   Han Dunzheng D   Ouyang Hong H   Pan Xiudi X   Luo Bihui B   Zhou Bohua B   Fu Qiang Q   Lu Dongfeng D   Huang Zheng Z   Li Zhiliang Z  

Frontiers in cell and developmental biology 20210630


<h4>Objective</h4>Regenerative therapy using mesenchymal stem cells (MSC) is a promising therapeutic method for critical limb ischemia (CLI). To understand how the cells are involved in the regenerative process of limb ischemia locally, we proposed a metabolic protein labeling method to label cell proteomes <i>in situ</i> and then decipher the proteome dynamics of MSCs in ischemic hind limb.<h4>Methods and results</h4>In this study, we overexpressed mutant methionyl-tRNA synthetase (MetRS), whic  ...[more]

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