Dataset Information
Proteomic analysis of leukocytes upon Plekhm1-KO
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Leukocyte, Bone Marrow
DISEASE(S): Acute Leukemia
SUBMITTER: 
Georg Tascher
LAB HEAD: Daniela Krause
PROVIDER: PXD027044 | Pride | 2023-01-16
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20201204_MAA_CK_F1.raw | Raw | |||
| 20201204_MAA_CK_F2.raw | Raw | |||
| 20201204_MAA_CK_F3.raw | Raw | |||
| 20201204_MAA_CK_F4.raw | Raw | |||
| 20201204_MAA_CK_F5.raw | Raw |
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Publications
Impact of mesenchymal stromal cell-derived vesicular cargo on B-cell acute lymphoblastic leukemia progression.
Blood advances 20230401 7
Leukemia cells reciprocally interact with their surrounding bone marrow microenvironment (BMM), rendering it hospitable to leukemia cell survival, for instance through the release of small extracellular vesicles (sEVs). In contrast, we show here that BMM deficiency of pleckstrin homology domain family M member 1 (PLEKHM1), which serves as a hub between fusion and secretion of intracellular vesicles and is important for vesicular secretion in osteoclasts, accelerates murine BCR-ABL1+ B-cell acute ...[more]
