Dataset Information

Human CK1 alpha (CK1α) 5'UTR-interacting proteins

ABSTRACT: We used tobramycin-affinity RNA-pulldown assays coupled with mass spectrometry to identify CK1α 5'-UTR-binding proteins.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Jit Kong Cheong

LAB HEAD: Jit Kong Cheong

PROVIDER: PXD027124 | Pride | 2022-10-01

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	190808_WXH_spl15_CK1a_SUTR_75_5ul.group	Other
	190808_WXH_spl15_CK1a_SUTR_75_5ul.wiff	Wiff
	190808_WXH_spl15_CK1a_SUTR_75_5ul.wiff.scan	Wiff
	190808_WXH_spl15_CK1a_SUTR_75_5ul__FDR.xlsx	Xlsx
	190808_WXH_spl16_VEH_75_5ul.group	Other

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Publications

SFPQ promotes RAS-mutant cancer cell growth by modulating 5'-UTR mediated translational control of CK1α.

Kok Venetia Jing Tong VJT Tang Jia Ying JY Eng Gracie Wee Ling GWL Tan Shin Yi SY Chin Joseph Tin Foong JTF Quek Chun Hian CH Lai Wei Xuan WX Lim Teck Kwang TK Lin Qingsong Q Chua John Jia En JJE Cheong Jit Kong JK

NAR cancer 20220927 3

Oncogenic mutations in the RAS family of small GTPases are commonly found in human cancers and they promote tumorigenesis by altering gene expression networks. We previously demonstrated that Casein Kinase 1α (CK1α), a member of the CK1 family of serine/threonine kinases, is post-transcriptionally upregulated by oncogenic RAS signaling. Here, we report that the CK1α mRNA contains an exceptionally long 5'-untranslated region (UTR) harbouring several translational control elements, implicating its ...[more]

PMID: 36177382

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