Proteomics

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Chorioallantoic membrane (CAM) and embryonic blood serum proteomics

ABSTRACT: In chickens, embryonic development begins upon egg formation and lasts for 21 days of incubation until hatching. The CAM is an extraembryonic membrane that serves a critical role in acid-base balance, gaseous exchange, calcium solubilization, and antimicrobial protection. Comparative proteomic analyses of CAM at two developmental stages (ED12 and ED19), in comparison to the proteome of embryonic blood serum, revealed protein groups that are relatively or highly specific to the CAM. The specific CAM functions include gaseous exchange, Ca2+ transport, vasculature development, and protection against pathogen invasion. Overall, our results highlight the structure-function relationship of the CAM protein constituents that potentially could expand its biomedical applications.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Embryo, Extraembryonic Membrane

SUBMITTER: Tamer Ahmed  

LAB HEAD: Maxwell T. Hincke

PROVIDER: PXD027129 | Pride | 2022-08-12

REPOSITORIES: Pride

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Chicken_CAM_and_serum_proteomics.sf3 Other
Chicken_CAM_and_serum_proteomics_Output.xlsx Xlsx
Chicken_CAM_and_serum_proteomics_PTM.sf3 Other
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Publications

Proteomic Analysis of Chicken Chorioallantoic Membrane (CAM) during Embryonic Development Provides Functional Insight.

Ahmed Tamer A E TAE   Cordeiro Cristianne M M CMM   Elebute Oluwadara O   Hincke Maxwell T MT  

BioMed research international 20220619

In oviparous animals, the egg contains all resources required for embryonic development. The chorioallantoic membrane (CAM) is a placenta-like structure produced by the embryo for acid-base balance, respiration, and calcium solubilization from the eggshell for bone mineralization. The CAM is a valuable <i>in vivo</i> model in cancer research for development of drug delivery systems and has been used to study tissue grafts, tumor metastasis, toxicology, angiogenesis, and assessment of bacterial i  ...[more]

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