Proteomics

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Analysis of components of Buxuetongluo Pills by LC-MS/MS


ABSTRACT: Buxue tongluo Pills(BTP) are a pill commonly used to treat osteonecrosis of the femoral head, but its composition and mechanism are unclear. As a result, we analyzed the components of BTP by LC-MS/MS.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Macrophage

DISEASE(S): Osteonecrosis

SUBMITTER: Dan Wang  

LAB HEAD: Yunhui Chen

PROVIDER: PXD027269 | Pride | 2022-02-17

REPOSITORIES: Pride

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Publications

Induction of PI3K/Akt-Mediated Apoptosis in Osteoclasts Is a Key Approach for <i>Buxue Tongluo</i> Pills to Treat Osteonecrosis of the Femoral Head.

Wang Dan D   Liu Yicheng Y   Tang Dandan D   Wei Shujun S   Sun Jiayi J   Ruan Lvqiang L   He Lin L   Li Ruolan R   Ren Qiang Q   Tian Xiaoping X   Chen Yunhui Y  

Frontiers in pharmacology 20211129


The <i>Buxue Tongluo</i> pill (BTP) is a self-made pill with the functions of nourishing blood, promoting blood circulation, dredging collaterals, and relieving pain. It consists of <i>Angelica sinensis</i> (Oliv.) Diels, <i>Pheretima aspergillum</i> (E.Perrier), <i>Panax notoginseng</i> (Burk.) F. H. Chen, <i>Astragalus membranaceus</i> (Fisch.) Bge, and <i>Glycyrrhiza uralensis</i> Fisch. Various clinical practices have confirmed the therapeutic effect of BTP on osteonecrosis of the femoral he  ...[more]

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