Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Macrophage
DISEASE(S): Disease Free
SUBMITTER: Berend Gagestein
LAB HEAD: Mario van der Stelt
PROVIDER: PXD027600 | Pride | 2023-04-28
REPOSITORIES: Pride
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Journal of the American Chemical Society 20221005 41
The fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3) is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of DHA are poorly understood. Here, we report the design, synthesis, and application of a complementary pair of bio-orthogonal, photoreactive probes based on the polyunsaturated scaffold DHA and its oxidative metabolite 17-hydroxydocosahexaenoic acid (17-HDHA). In these probes, an alkyne serves as a handle to introduce a f ...[more]