Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Primary Cell, Keratinocyte, Skin
SUBMITTER: Manfred Heller
LAB HEAD: Martin Degen
PROVIDER: PXD027669 | Pride | 2022-02-17
REPOSITORIES: Pride
Items per page: 1 - 5 of 38 |
Frontiers in cell and developmental biology 20210930
Variants within the gene encoding for the transcription factor Interferon Regulatory Factor 6 (IRF6) are associated with syndromic and non-syndromic Cleft Lip/Palate (CLP) cases. IRF6 plays a vital role in the regulation of the proliferation/differentiation balance in keratinocytes and is involved in wound healing and migration. Since a fraction of CLP patients undergoing corrective cleft surgery experience wound healing complications, <i>IRF6</i> represents an interesting candidate gene linking ...[more]