Dataset Information

Leptin-deficient Mouse Liver TMT-label Discovery Proteomics Profiling

ABSTRACT: The aim of this project was to profile the proteome of mouse-derived liver in order to identify those that showed significant quantitative different proteins among leptin-deficient (db/db) mouse, the genetic non-alcoholic fatty liver disease (NAFLD) mouse model and their lean BKS mouse group.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Yu Zhang

LAB HEAD: Suowen Xu

PROVIDER: PXD027938 | Pride | 2022-10-14

REPOSITORIES: Pride

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Publications

Comparative Proteomic Analysis of Liver Tissues and Serum in <i>db</i>/<i>db</i> Mice.

Zhang Yu Y Wu Xiumei X Xu Mengyun M Yue Tong T Ling Ping P Fang Tingyu T Luo Sihui S Xu Suowen S Weng Jianping J

International journal of molecular sciences 20220826 17

<h4>Background and aims</h4>Non-alcoholic fatty liver disease (NAFLD) affects one-quarter of individuals worldwide. Liver biopsy, as the current reliable method for NAFLD evaluation, causes low patient acceptance because of the nature of invasive sampling. Therefore, sensitive non-invasive serum biomarkers are urgently needed.<h4>Results</h4>The serum gene ontology (GO) classification and Kyoto encyclopedia of genes and genomes (KEGG) analysis revealed the DEPs enriched in pathways including JAK ...[more]

PMID: 36077090

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